Per‐ and poly‐fluoroalkyl substances (PFAS) have achieved prominence in terms of public visibility and regulatory concern not seen since endocrine‐disrupting chemicals were identified as a potential widespread risk to human health and the environment more than two decades ago. Mutigenerational effects of are of interest due to their persistent, bioaccumulative, and toxic (PBT) nature. The toxicological responses in multigenerational tests can follow non-monotonic dose responses and this could be related to multiple mechanisms of these chemicals. In this presentation, I will briefly give some examples and share our recent findings.